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Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

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Specifically, information on glutathione status in older adults considered generally healthy is currently limited and therefore the benefits of GlyNAC supplementation in such a population are not well established